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On the basis of this method, we defined clinical significance as a difference of 8 points or more on the physical-limitation scale, 25 or more on the angina-stability scale, 20 or more on the angina-frequency scale, 12 or more on the treatment-satisfaction scale, and 16 or more on the quality-of-life scale.
In patients with LQT3 (long QT syndrome type 3), a monogenic disorder in which the electrophysiological phenotype is due to an increase in INaL, ranolazine has been shown to cause a dose-dependent abbreviation of the QTc.
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Because acetylcholine is the cardiac parasympathetic neurotransmitter, and because the acetylcholine-activated hyperpolarizing current I KAch, Ado is reportedly increased in atrial cells of patients with AF, the combination of dronedarone and ranolazine may be beneficial to reduce the incidence of AF in patients susceptible to the disease.
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Increase in trough symptom-limited exercise duration (the primary endpoint) was significantly greater in both ranolazine groups compared with placebo.
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The methods of this aspect of the invention are preferably achieved by administering to the presenting patient an IV solution comprising a selected concentration of ranolazine.
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Importantly, a normal electrocardiogram does not exclude coronary artery disease ().
You may take ranolazine with or without food, but should try to take it the same way every time.
Although the relative number of patients is relatively small, there is no evidence that the treatment effects of ranolazine within any of these particular subgroups were inconsistent with the results observed in the overall population, although the placebo-corrected increase in treadmill exercise duration on ranolazine was less in women than in men.
Ranolazine is primarily metabolized by CYP3A and is a substrate of P-gp.
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The method comprises coadministration of a synergistically therapeutic amount of dronedarone or a pharmaceutically acceptable salt or salts thereof and a synergistically therapeutic amount of ranolazine or a pharmaceutically acceptable salt or salts thereof.
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The active agents of the invention are effective over a wide dosage range and are generally administered in a pharmaceutically effective amount.
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