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Because acetylcholine is the cardiac parasympathetic neurotransmitter, and because the acetylcholine-activated hyperpolarizing current I KAch, Ado is reportedly increased in atrial cells of patients with AF, the combination of dronedarone and ranolazine may be beneficial to reduce the incidence of AF in patients susceptible to the disease.

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Increase in trough symptom-limited exercise duration (the primary endpoint) was significantly greater in both ranolazine groups compared with placebo.

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Although the relative number of patients is relatively small, there is no evidence that the treatment effects of ranolazine within any of these particular subgroups were inconsistent with the results observed in the overall population, although the placebo-corrected increase in treadmill exercise duration on ranolazine was less in women than in men.

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The method comprises coadministration of a synergistically therapeutic amount of dronedarone or a pharmaceutically acceptable salt or salts thereof and a synergistically therapeutic amount of ranolazine or a pharmaceutically acceptable salt or salts thereof.

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